Anastrazole is a newer drug developed for treating advanced breast cancer in women. Anastrazole is the first in a new class of third-generation selective oral aromatase inhibitors.. It acts by blocking the enzyme aromatase, subsequently blocking estrogen production. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body, the progression of such a disease can be halted. This is the basic premise behind Nolvadex, except this drug blocks the action and not the estrogen production. The effects of Anastrazole can be pretty dramatic, to say the least. A daily dose of one tablet (1 mg) can produce estrogen suppression greater than 80 % in treated patients. With this drug's powerful effect on hormone levels, it is only to be used (clinically) by post-menopausal women whose disease has progressed following treatment with Nolvadex (tamoxifen citrate). Side effects like hot flushes and hair thinning can be present and would no doubt be much more severe in pre-menopausal patients. For the steroid-using male athlete, Anastrazole shows excellent potential. Until now, drugs like Tamoxifen and Proviron have been our weapons against excess estrogen. These drugs, especially in combination, do prove quite effective. But Anastrazole can do the job much more efficiently and with less hassle. A single tablet daily (1 mg), the same dose used clinically, seems to be all one needs for an exceptional effect (some even report excellent results with only 0.25 mg daily). When used with potent, readily aromatizing androgens such as Dianabol or testosterone, gynecomastia and water retention can be effectively blocked. In combination with Propecia (finasteride), we have a significant advance. With one drug halting estrogen conversion and the other blocking 5-alpha reduction, related side effects can be effectively minimized. Here the strong androgen testosterone could theoretically provide incredible muscular growth while at the same time being as tolerable as nandrolone. Additionally, the muscle quality should be greater, with the athlete appearing harder and more defined without holding excess water.